The Research and Development Survey (RANDS) is a series of cross-sectional surveys using probability-sampled commercial survey panels. The sixth round of RANDS (RANDS 6) was administered by NORC at the University of Chicago using the AmeriSpeak Panel from August 10, 2022 to August 29, 2022. RANDS 6 contained the embedded probe questions and experiments as in previous rounds of RANDS. It also explored different administrations of questions asked on the National Survey of Family Growth (NSFG) through split-sample experiments. RANDS 6 has a known survey sampling design and can be used to produce nationally and sub-nationally representative estimates.