The in vitro micronucleus assay provides insight into the genotoxic damage potential of test articles by measuring the frequency of micronuclei in mammalian cell cultures. Flow cytometry is commonly used to measure DNA damage in cell cultures by counting harvested cells to determine the percentage of cells that are micronucleated. In vitro micronucleus data can include cell counts, percentages of micronucleated cells, and percentages of apoptotic cells.
This data domain is part of Chemical Effects in Biological Systems (CEBS) database maintained by the National Toxicology Program.
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