Immunotoxicology identifies the potential for a test article to modulate immune function in mice and/or rats. This data domain contains studies that evaluate the basic functional aspects of diverse immune system components including innate immune function and adaptive immune function (humoral mediated immunity, cell-mediated immunity). Examples of endpoints: function (phagocytosis), natural killer cell assay, cytotoxic T lymphocyte activity, proliferative responses that signal through the T cell receptor, IgM and IgG antibody production following challenge with T-dependent antigens, and quantification of leukocyte populations.
This data domain also includes studies that evaluate the potential for test articles to induce dermal sensitization (contact hypersensitivity) and irritancy following application to the skin. Examples of endpoints: proliferative responses in the lymph nodes that drain the site of test article application and measurements of edema at the site of exposure.
This dataset also comprises studies that assess the ability of test articles to trigger or modulate existing autoimmunity. These studies are disease specific and the endpoints vary in accordance with the specific disease being investigated. Examples of endpoints: serum and urinary proteins, measurement of circulating or tissue specific autoantibodies, and other inflammatory mediators.
This data domain is part of Chemical Effects in Biological Systems (CEBS) database maintained by the National Toxicology Program.
At the link provided is a PDF and one or more folders containing data. The PDF describes the data, file types, and folder structure present.